Rauzan-ségla was once part of the vast rausan estate owned by pierre de mesures de rauzan in the mid-17th century. Over time, this estate was divided, and by the time of the 1855 classification, had been separated into the estates of château rauzan-gassies, château rauzan-ségla, château desmirail, and château marquis de terme.

After a long ownership by the durand-dasier family, the estate was acquired by frédéric cruse of the cruse family in 1903 who held ownership until 1957, and until 1989 it belonged to liverpool shipping magnate john holt. by 1982 the estate had hired the consultant services of émile peynaud, and in 1989 the property was purchased by brent walker. whatever plans he had, however, were not to bear fruit; in 1994 he sold the estate on to the wertheimer family of chanel, who installed a winemaking team led by david orr and john kolasa (both from chateau latour). Chanel remain the current owners, and they are credited with continuing to push the quality ever higher.