Disaronno Originale is crafted from an infusion of apricot kernel oil and a proprietary blend of seventeen herbs and fruits in absolute alcohol. Despite its characteristic almond and marzipan flavour profile, Disaronno contains no almonds: the distinctive flavour derives from apricot kernel oil combined with burnt sugar and seventeen confidential botanical and fruit ingredients, with the formulation unchanged since the brand's formal establishment in 1947. The infusion is then blended with spirit and water to reach 20% ABV. Disaronno is one of the world's most recognised Italian liqueur brands and a reference standard for the amaretto category globally.

Disaronno is produced in Saronno, in the Lombardy region of northern Italy, by ILLVA Saronno — a house whose origins trace to Domenico Reina's shop in Saronno in 1900. The Disaronno brand was formally established in 1947, and the recipe is said to derive from a liqueur first created in Saronno in 1525. By tradition, the original recipe was gifted to the Renaissance painter Bernardino Luini by a local innkeeper during the commission of a fresco in Saronno. The liqueur carries the name 'di Saronno' — 'of Saronno' in Italian — in recognition of its deep roots in the city and its surrounding Lombard countryside.